84880-03-5
Chemical Structure
Cefpimizole
Synonym(s): U-63196E; AC-1370
- CAS No.: 84880-03-5
- Formula:C28H26N6O10S2
- Molecular Weight:670.67
IUPAC Name: (6R,7R)-7-((R)-2-(4-carboxy-1H-imidazole-5-carboxamido)-2-phenylacetamido)-8-oxo-3-((4-(2-sulfoethyl)pyridin-1-ium-1-yl)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: LNZMRLHZGOBKAN-KAWPREARSA-N
SMILES: [O-]C(C1=C(C[N+]2=CC=C(CCS(=O)(O)=O)C=C2)CS[C@@]([C@@H]3NC([C@@H](C4=CC=CC=C4)NC(C5=C(N=CN5)C(O)=O)=O)=O)([H])N1C3=O)=O
Biological Activity: Cefpimizole (U-63196E) is a broad-spectrum cephalosporin antibiotic. Cefpimizole inhibits many Ampicillin (HY-B0522)-resistant bacteria, and is active against gram-negative species. Cefpimizole augments phagocytosis of macrophages and neutrophils[1][2].
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Cefpimizole | Cefpimizole (U-63196E) is a broad-spectrum cephalosporin antibiotic. Cefpimizole inhibits many Ampicillin (HY-B0522)-resistant bacteria, and is active against gram-negative species. Cefpimizole augments phagocytosis of macrophages and neutrophils. | |||||||||||||||||||||
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References
- [1]. Neu HC, et al. In vitro activity and beta-lactamase stability of U-63196E, a novel cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):375-82. [Content Brief]
- [2]. Ohnishi H, et al. Effects of AC-1370, a new semisynthetic cephalosporin, on phagocyte functions. Antimicrob Agents Chemother. 1983 Jun;23(6):874-80. [Content Brief]
