84957-29-9
Chemical Structure
Cefpirome
Synonym(s): HR 810
- CAS No.: 84957-29-9
- Formula:C22H22N6O5S2
- Molecular Weight:514.58
IUPAC Name: (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: DKOQGJHPHLTOJR-WHRDSVKCSA-N
SMILES: O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@@]3([H])SCC(C[N+]4=CC=CC5=C4CCC5)=C(C([O-])=O)N13
Biological Activity: Cefpirome (HR-810) is a cephalosporin antibiotic that can cross cell membranes and the blood-brain barrier. Cefpirome binds to penicillin-binding proteins with high affinity, thereby inhibiting bacterial cell wall synthesis. Cefpirome exhibits bactericidal and growth-inhibitory activities against Gram-negative bacteria, Gram-positive bacteria, and susceptible anaerobic bacteria (including some β-lactamase-producing strains)[1][2][3].
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Cefpirome | Cefpirome (HR-810) is a cephalosporin antibiotic that can cross cell membranes and the blood-brain barrier. Cefpirome binds to penicillin-binding proteins with high affinity, thereby inhibiting bacterial cell wall synthesis. Cefpirome exhibits bactericidal and growth-inhibitory activities against Gram-negative bacteria, Gram-positive bacteria, and susceptible anaerobic bacteria (including some β-lactamase-producing strains). | |||||||||||||||||||||
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References
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[1]. Wiseman LR, et al. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia. Drugs. 1997 Jul;54(1):117-40.
[Content Brief] -
[2]. Gautam V, et al. Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection. Microb Drug Resist. 2020 Apr;26(4):341-348.
[Content Brief] - [3]. Bertram MA, et al. In vitro activity of HR 810, a new cephalosporin. Antimicrob Agents Chemother. 1984;26(2):277-279. [Content Brief]
