850715-59-2
850715-59-2
Chemical Structure
SAMT-247
- CAS 番号: 850715-59-2
- Formula:C12H14N2O3S
- Molecular Weight:266.32
IUPAC Name: S-(2-((3-amino-3-oxopropyl)carbamoyl)phenyl) ethanethioate
InChIKey: UNACIIIRYSLSOD-UHFFFAOYSA-N
SMILES: CC(SC1=CC=CC=C1C(NCCC(N)=O)=O)=O
Biological Activity: SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].
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SAMT-247 | SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity. | |||||||||||||||||||||
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References
- [1]. Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204(12):3315-3328. [Content Brief]
- [2]. Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6(12):887-9. [Content Brief]
