852453-71-5
Chemical Structure
LASSBio-1135
- CAS No.: 852453-71-5
- Formula:C18H14N4
- Molecular Weight:286.33
IUPAC Name: N-phenyl-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine
InChIKey: ULQALHCOPZRDMC-UHFFFAOYSA-N
SMILES: C12=NC(C3=NC=CC=C3)=C(NC4=CC=CC=C4)N1C=CC=C2
Biological Activity: LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem[1].
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LASSBio-1135 | 99.05% | LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem. | ||||||||||||||||||||
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Keywords
