859209-84-0
Chemical Structure
GS-9191
- CAS No.: 859209-84-0
- Formula:C37H51N8O6P
- Molecular Weight:734.82
IUPAC Name: diisobutyl 2,2'-((((2-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)ethoxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-bis(3-phenylpropanoate)
InChIKey: YTMOQFAFGKLYIW-CONSDPRKSA-N
SMILES: CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O
Biological Activity: GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection[1].
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GS-9191 | GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection. | |||||||||||||||||||||
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