859213-87-9
859213-87-9
Chemical Structure
Glu-AMS
- CAS No.: 859213-87-9
- Formula:C15H21N7O9S
- Molecular Weight:475.43
InChIKey: YBRKRYFZKHICLS-WERHYGNASA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(NC([C@@H](N)CCC(O)=O)=O)(=O)=O
Biological Activity: Glu-AMS is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), with the Ki of 2.8 nM[1].
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Glu-AMS | Glu-AMS is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), with the Ki of 2.8 nM. | |||||||||||||||||||||
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References
- [1]. Sébastien P Blais, et al. tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications. PLoS One. 2015 Jun 3;10(6):e0130238. [Content Brief]
