86696-87-9
86696-87-9
Chemical Structure
Aganodine
- CAS No.: 86696-87-9
- Formula:C9H10Cl2N4
- Molecular Weight:245.11
IUPAC Name: 1-(4,7-dichloroisoindolin-2-yl)guanidine
InChIKey: DFKHOVYSCCPSHR-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=C1CN(C2)NC(N)=N)Cl
Biological Activity: Aganodine is a guanidine that activates presynaptic imidazoline receptors and can inhibit electrically evoked [3H]-norepinephrine release[1][2][3].
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Aganodine | Aganodine is a guanidine that activates presynaptic imidazoline receptors and can inhibit electrically evoked [3H]-norepinephrine release. | |||||||||||||||||||||
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References
- [1]. Molderings G J, et al. Presynaptic imidazoline receptors and non‐adrenoceptor [3H]‐idazoxan binding sites in human cardiovascular tissues[J]. British journal of pharmacology, 1997, 122(1): 43-50.
- [2]. Göthert M, et al. α2‐Adrenoceptor‐independent inhibition by imidazolines and guanidines of noradrenaline release from peripheral, but not central noradrenergic neurons[J]. Annals of the New York Academy of Sciences, 1995, 763(1): 405-419.
- [3]. Schlicker E, et al. Effects of imidazolines in noradrenaline release in brain: An investigation into their relationship to imidazoline, α2 and H3 receptors[J]. Neurochemistry international, 1997, 30(1): 73-83. [Content Brief]
Keywords
