868265-28-5
868265-28-5
Chemical Structure
LY2365109
- CAS No.: 868265-28-5
- Formula:C22H27NO5
- Molecular Weight:385.45
IUPAC Name: 2-((2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid
InChIKey: FKPLJWGRBCQLTL-UHFFFAOYSA-N
SMILES: O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C
Biological Activity: LY2365109 is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
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LY2365109 | LY2365109 is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. | |||||||||||||||||||||
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References
- [1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. [Content Brief]
- [2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65. [Content Brief]
Keywords
