874339-65-8
874339-65-8
Chemical Structure
PPL-100 free acid
- CAS No.: 874339-65-8
- Formula:C33H45N4O9PS
- Molecular Weight:704.77
IUPAC Name: methyl ((S)-1-(((S)-5-((4-amino-N-isobutylphenyl)sulfonamido)-6-(phosphonooxy)hexyl)amino)-1-oxo-3,3-diphenylpropan-2-yl)carbamate
InChIKey: KHASNRBNVBIREH-IZEXYCQBSA-N
SMILES: CC(CN(S(=O)(C1=CC=C(N)C=C1)=O)[C@H](COP(O)(O)=O)CCCCNC([C@@H](NC(OC)=O)C(C2=CC=CC=C2)C3=CC=CC=C3)=O)C
Biological Activity: PPL-100 free acid is a potential agent for SERPINA1. PPL-100 free acid can be metabolically cleaved into PL-100 (HY-107468)[1][2].
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PPL-100 free acid | PPL-100 free acid is a potential agent for SERPINA1. PPL-100 free acid can be metabolically cleaved into PL-100 (HY-107468). | |||||||||||||||||||||
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References
- [1]. Dandache S, et, al. PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63. [Content Brief]
- [2]. Qu T, et, al. Identification of potential biomarkers and drugs for papillary thyroid cancer based on gene expression profile analysis. Mol Med Rep. 2016 Dec;14(6):5041-5048. [Content Brief]
