874887-03-3
Chemical Structure
JNJ-17166864
- CAS No.: 874887-03-3
- Formula:C21H25Cl3N2O2
- Molecular Weight:443.79
IUPAC Name: N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyltetrahydro-2H-pyran-4-aminium chloride
InChIKey: VALRCWBOFWDEDE-UHFFFAOYSA-N
SMILES: C[N+](C)(CC1=CC=C(NC(C2=CC=C(Cl)C(Cl)=C2)=O)C=C1)C3CCOCC3.[Cl-]
Biological Activity: JNJ-17166864 is a highly selective CCR2 antagonist. JNJ-17166864 has low oral bioavailability. JNJ-17166864 can significantly reduce the area of alveolar bone loss in a mouse model of periodontitis induced by Porphyromonas gingivalis infection. JNJ-17166864 can be used in the research of inflammatory diseases such as allergic rhinitis and periodontitis[1][2].
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JNJ-17166864 | JNJ-17166864 is a highly selective CCR2 antagonist. JNJ-17166864 has low oral bioavailability. JNJ-17166864 can significantly reduce the area of alveolar bone loss in a mouse model of periodontitis induced by Porphyromonas gingivalis infection. JNJ-17166864 can be used in the research of inflammatory diseases such as allergic rhinitis and periodontitis. | |||||||||||||||||||||
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References
- [1]. Covino DA, et al. The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy? Curr Drug Targets. 2016;17(1):76-110. [Content Brief]
- [2]. Zhang J, et al. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res. 2012 Dec 1;96(3):543-51. [Content Brief]
