87687-02-3
87687-02-3
Chemical Structure
Resorufin benzyl ether
Synonym(s): BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone
- CAS. Nr.: 87687-02-3
- Formula:C19H13NO3
- Molecular Weight:303.31
IUPAC Name: 7-(benzyloxy)-3H-phenoxazin-3-one
InChIKey: XNZRYTITWLGTJS-UHFFFAOYSA-N
SMILES: O=C1C=CC2=NC3=C(C=C(OCC4=CC=CC=C4)C=C3)OC2=C1
Biological Activity: Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO- detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm[1][2][3].
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Resorufin benzyl ether | Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO- detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm. | |||||||||||||||||||||
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References
- [1]. Ji X, et al. Regulating the activity of boronate moiety to construct fluorescent probes for the detection of ONOO-in vitro and in vivo. Anal Methods. 2022 Dec 15;14(48):5027-5033. [Content Brief]
- [2]. Nuchtavorn N, et al. Paper-based sol-gel thin films immobilized cytochrome P450 for enzyme activity measurement. Anal Chim Acta. 2020 Feb 15;1098:86-93. [Content Brief]
- [3]. Yale SH, et al. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med. 2005 Jun;11(3):433-9. [Content Brief]
