87691-91-6
Chemical Structure
Tiospirone
Synonym(s): BMY 13859-1 free base
- CAS No.: 87691-91-6
- Formula:C24H32N4O2S
- Molecular Weight:440.60
IUPAC Name: 8-(4-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione
InChIKey: ZFZPJDFBJFHYIV-UHFFFAOYSA-N
SMILES: O=C1N(CCCCN2CCN(CC2)C3=NSC4=C3C=CC=C4)C(CC5(CCCC5)C1)=O
Biological Activity: Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].
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Tiospirone | Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm. | |||||||||||||||||||||
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- [1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8. [Content Brief]
- [2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81. [Content Brief]
Keywords
