878189-87-8
Chemical Structure
Amustaline
Synonym(s): S-303
- CAS No.: 878189-87-8
- Formula:C22H25Cl2N3O2
- Molecular Weight:434.36
IUPAC Name: 2-(bis(2-chloroethyl)amino)ethyl 3-(acridin-9-ylamino)propanoate
InChIKey: BDLWRIAFNYVGTC-UHFFFAOYSA-N
SMILES: O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl
Biological Activity: Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Amustaline | Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Aubry M, et al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components. [Content Brief]
- [2]. Aydinok Y, et al. Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia. Br J Haematol. 2019 Aug;186(4):625-636. [Content Brief]
Keywords
