885986-52-7
Chemical Structure
N-Myc-IN-1
- No. CAS: 885986-52-7
- Formula:C15H13BrN4O2
- Molecular Weight:361.19
InChIKey: GAHGQYZYTCCYEP-UHFFFAOYSA-N
SMILES: O=C(CBr)NC1=CC2=NN(C3=CC=C(C=C3)OC)N=C2C=C1
Biological Activity: N-Myc-IN-1 is a selective N-Myc inhibitor/degrader with a Kd value of 1.47 μM. N-Myc-IN-1 promotes phosphorylation of N-Myc at threonine-58, triggers N-Myc degradation via the ubiquitin-proteasome pathway, and suppresses the expression of N-Myc target genes. N-Myc-IN-1 reduces the viability of MYCN-dependent tumor cells and induces apoptosis. N-Myc-IN-1 can be used in the research of neuroblastoma[1].
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N-Myc-IN-1 | N-Myc-IN-1 is a selective N-Myc inhibitor/degrader with a Kd value of 1.47 μM. N-Myc-IN-1 promotes phosphorylation of N-Myc at threonine-58, triggers N-Myc degradation via the ubiquitin-proteasome pathway, and suppresses the expression of N-Myc target genes. N-Myc-IN-1 reduces the viability of MYCN-dependent tumor cells and induces apoptosis. N-Myc-IN-1 can be used in the research of neuroblastoma. | |||||||||||||||||||||
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Keywords
