891-60-1
Chemical Structure
Declopramide
Synonym(s): 3-Chloroprocainamide
- CAS No.: 891-60-1
- Formula:C13H20ClN3O
- Molecular Weight:269.77
IUPAC Name: 4-amino-3-chloro-N-(2-(diethylamino)ethyl)benzamide
InChIKey: YEYAKZXEBSVURO-UHFFFAOYSA-N
SMILES: O=C(NCCN(CC)CC)C1=CC=C(N)C(Cl)=C1
Biological Activity: Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research[1][2][3].
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Declopramide | Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research. | |||||||||||||||||||||
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- [1]. Hua J, et al., Comparison of antitumor activity of declopramide (3-chloroprocainamide) and N-acetyl-declopramide. Anticancer Res. 1999 Jan-Feb;19(1A):285-90. [Content Brief]
- [2]. Hua J, et al., Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. [Content Brief]
- [3]. Lindgren H, et al., Differential usage of IkappaBalpha and IkappaBbeta in regulation of apoptosis versus gene expression. Biochem Biophys Res Commun. 2003 Jan 31;301(1):204-11. [Content Brief]
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