89575-11-1
89575-11-1
Chemical Structure
AURKA-IN-4
- CAS No.: 89575-11-1
- Formula:C12H17NO3
- Molecular Weight:223.27
InChIKey: HYGXNCVIGJQTAQ-UHFFFAOYSA-N
SMILES: COC1=CC(CNC(CCC)=O)=CC=C1O
Biological Activity: AURKA-IN-4 is a Capsaicin (HY-10448)-derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A (AURKA) and PHB2. AURKA-IN-4 binds to the active site of AURKA and the inhibitory pocket of PHB2, inhibits AURKA-dependent mitophagy, and increases mitochondrial mass in cancer cells overexpressing AURKA. AURKA-IN-4 can be used in the research of breast cancer[1].
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AURKA-IN-4 | 99.88% | AURKA-IN-4 is a Capsaicin (HY-10448)-derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A (AURKA) and PHB2. AURKA-IN-4 binds to the active site of AURKA and the inhibitory pocket of PHB2, inhibits AURKA-dependent mitophagy, and increases mitochondrial mass in cancer cells overexpressing AURKA. AURKA-IN-4 can be used in the research of breast cancer. | ||||||||||||||||||||
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