897369-18-5
897369-18-5
Chemical Structure
BCR-ABL-IN-2
- CAS. Nr.: 897369-18-5
- Formula:C24H25Cl2N5O3
- Molecular Weight:502.39
IUPAC Name: (S)-6-(3-(tert-butyl)-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChIKey: CMUVVEBHULJOFP-SFHVURJKSA-N
SMILES: O=C([C@H]1NCC2=C(C=C(N3N=C(C(C)(C)C)C=C3NC(NC4=CC=CC(Cl)=C4Cl)=O)C=C2)C1)O
Biological Activity: BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.
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BCR-ABL-IN-2 | BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. | |||||||||||||||||||||
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