900779-63-7
900779-63-7
Chemical Structure
5-CITEP
- CAS No.: 900779-63-7
- Formula:C12H8ClN5O2
- Molecular Weight:289.68
IUPAC Name: (Z)-1-(5-chloro-1H-indol-2-yl)-3-hydroxy-3-(1H-tetrazol-5-yl)prop-2-en-1-one
InChIKey: HPVBQJCFJVPPQC-WZUFQYTHSA-N
SMILES: O=C(C=C(O)C1=NN=NN1)C2=CC=3C=C(Cl)C=CC3N2
Biological Activity:
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5-CITEP | 5 CITEP is a potent HIV integrase inhibitor; its IC50s by multiple MIA and MPA are 2. | |||||||||||||||||||||
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References
- Goldgur Y, et al. Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13040-3. [Content Brief]
- Johnson AA, et al. Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop. J Biol Chem. 2006 Jan 6;281(1):461-7. [Content Brief]
Keywords
