90326-85-5
Chemical Structure
Nesapidil
- CAS No.: 90326-85-5
- Formula:C23H28N4O4
- Molecular Weight:424.50
IUPAC Name: 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)propan-2-ol
InChIKey: FYKZHAJQLBLBJO-UHFFFAOYSA-N
SMILES: OC(COC1=CC=CC(=C1)C2=NN=C(O2)C)CN3CCN(C=4C=CC=CC4OC)CC3
Biological Activity: Nesapidil is an antiarrhythmic agent and calcium channel blocker. Nesapidil slows calcium channel activity, which in turn causes slowing of atrioventricular conduction and sinus heart rate. Nesapidil alters preload, afterload, contractility, and coronary blood flow. Nesapidil can be used in research related to arrhythmia and hypertensionsup>[1][2][3][4].
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Nesapidil | Nesapidil is an antiarrhythmic agent and calcium channel blocker. Nesapidil slows calcium channel activity, which in turn causes slowing of atrioventricular conduction and sinus heart rate. Nesapidil alters preload, afterload, contractility, and coronary blood flow. Nesapidil can be used in research related to arrhythmia and hypertensionsup>. | |||||||||||||||||||||
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- [2]. Ahmad H, et al. Synthesis of 1, 3, 4-oxadiazole derivatives via transition metal catalyzed cross-coupling and their biological evaluation as selective inhibitors of Ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)-2,-3 and-8 inhibitors[J]. Journal of Molecular Structure, 2025, 1344: 142731.
- [3]. Somani R R, et al. Oxadiazole: A biologically important heterocycle[J]. ChemInform, 2011, 42(10): no.
- [4]. Rashidov S Z, et al. 5-(p-ASETILAMIDOFENIL)-1, 3, 4-OKSADIAZOL-2-TIONNING PSIXOSEDATIV FAOLLIGI[J]. ОСНОВЫ МЕДИЦИНЫ, 2026, 1(13): 46-50.
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