904309-12-2
904309-12-2
Chemical Structure
DWP-05195
- CAS No.: 904309-12-2
- Formula:C18H10BrF3N4
- Molecular Weight:419.20
SMILES: FC(F)(C1=CC=CN=C1C2=CC=C(C3=NC4=C(N3)C=C(Br)C=C4)N=C2)F
Biological Activity: DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells[1][2].
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DWP-05195 | DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells. | |||||||||||||||||||||
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References
- [1]. Wang YY, et, al. TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells. Cancers (Basel). 2020 Jun 26;12(6):1702. [Content Brief]
- [2]. Lee J, et, al. A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers. Drug Des Devel Ther. 2017 Apr 24:11:1301-1313. [Content Brief]
Keywords
