DWP-05195
DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 904309-12-2
- Formula: C18H10BrF3N4
- Molecular Weight:419.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 904309-12-2
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Molecular Weight 419.20
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Formula C18H10BrF3N4
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SMILES
FC(F)(C1=CC=CN=C1C2=CC=C(C3=NC4=C(N3)C=C(Br)C=C4)N=C2)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang YY, et, al. TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells. Cancers (Basel). 2020 Jun 26;12(6):1702. [Content Brief]
[2]. Lee J, et, al. A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers. Drug Des Devel Ther. 2017 Apr 24:11:1301-1313. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DWP-05195 Related Classifications
HY-167868 Related Classifications
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