9080-33-5
Chemical Structure
Succinyl-CoA synthetase
- CAS No.: 9080-33-5
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Succinyl-CoA synthetase]
Biological Activity: Succinyl-CoA synthetase is a mitochondrial matrix enzyme and catalyst. Succinyl-CoA synthetase supports TCA, ketone and heme metabolism and is activated by mitochondrial phosphate. Succinyl-CoA synthetase distributes broadly across mammalian tissues with distinct substrate-related biochemical features. Succinyl-CoA synthetase gains structural stability after phosphorylation and relies on SUCLG1-encoded subunit for activity. Succinyl-CoA synthetase malfunction links to metabolic and neurological disorders. Succinyl-CoA synthetase serves as a research tool for mitochondrial hepatoencephalomyopathy[1][2][3].
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Succinyl-CoA synthetase | Succinyl-CoA synthetase is a mitochondrial matrix enzyme and catalyst. Succinyl-CoA synthetase supports TCA, ketone and heme metabolism and is activated by mitochondrial phosphate. Succinyl-CoA synthetase distributes broadly across mammalian tissues with distinct substrate-related biochemical features. Succinyl-CoA synthetase gains structural stability after phosphorylation and relies on SUCLG1-encoded subunit for activity. Succinyl-CoA synthetase malfunction links to metabolic and neurological disorders. Succinyl-CoA synthetase serves as a research tool for mitochondrial hepatoencephalomyopathy. | |||||||||||||||||||||
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References
- [1]. Li X, et al. Identification of the kinetic mechanism of succinyl-CoA synthetase. Biosci Rep. 2013;33(1):145-163. Published 2013 Jan 18. [Content Brief]
- [2]. Bridger WA. Succinyl-Coa Synthetase. In: Boyer PD, editor. The Enzymes. Vol 10; 1974. p.581-606.
- [3]. Van Hove JL, et al. Succinyl-CoA ligase deficiency: a mitochondrial hepatoencephalomyopathy. Pediatr Res. 2010;68(2):159-164. [Content Brief]
