91441-48-4
91441-48-4
Chemical Structure
Teloxantrone
Synonym(s): CI-937; DUP 937
- CAS No.: 91441-48-4
- Formula:C21H25N5O4
- Molecular Weight:411.45
IUPAC Name: 7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)dibenzo[cd,g]indazol-6(2H)-one
InChIKey: XASBSYHEEHVCSJ-UHFFFAOYSA-N
SMILES: CNCCNC1=C2C3=C(C=C1)N(CCNCCO)N=C3C4=C(C(O)=CC=C4O)C2=O
Biological Activity: Teloxantrone (CI-937; DUP 937) is a DNA synthesis inhibitor (IC50: 0.33 μM). Teloxantrone has antitumor activity and can be used in colorectal cancer research[1][2].
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Teloxantrone | Teloxantrone (CI-937; DUP 937) is a DNA synthesis inhibitor (IC50: 0.33 μM). Teloxantrone has antitumor activity and can be used in colorectal cancer research. | |||||||||||||||||||||
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References
- [1]. Fry DW, et al. In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles). Biochem Pharmacol. 1985 Oct 1;34(19):3499-508. [Content Brief]
- [2]. Maroun JA, et al. Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Invest New Drugs. 1993 May-Aug;11(2-3):235-7. [Content Brief]
Keywords
