Teloxantrone
Teloxantrone (CI-937; DUP 937) is a DNA synthesis inhibitor (IC50: 0.33 μM). Teloxantrone has antitumor activity and can be used in colorectal cancer research.
For research use only. We do not sell to patients.
- CAS No.: 91441-48-4
- Formula: C21H25N5O4
- Molecular Weight:411.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
1.4 x 10-7M
Compound: 74
|
Tested in vitro against murine L1210 leukemia.
Tested in vitro against murine L1210 leukemia.
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[PMID: 3806589] |
| L1210 | IC50 |
1.40E-07 M
Compound: 74
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Tested in vitro against murine L1210 leukemia.
Tested in vitro against murine L1210 leukemia.
|
[PMID: 3806589] |
Chemical Information
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CAS No. 91441-48-4
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Molecular Weight 411.45
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Formula C21H25N5O4
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SMILES
CNCCNC1=C2C3=C(C=C1)N(CCNCCO)N=C3C4=C(C(O)=CC=C4O)C2=O
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Synonyms
CI-937; DUP 937
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fry DW, et al. In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles). Biochem Pharmacol. 1985 Oct 1;34(19):3499-508. [Content Brief]
[2]. Maroun JA, et al. Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Invest New Drugs. 1993 May-Aug;11(2-3):235-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Teloxantrone Related Classifications
HY-106090 Related Classifications
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