917104-47-3
Chemical Structure
C20-Dihydrosphingomyelin
Synonym(s): C20-DHSM; DHSM (d18:0/20:0)
- CAS No.: 917104-47-3
- Formula:C43H89N2O6P
- Molecular Weight:761.15
IUPAC Name: (2S,3R)-3-hydroxy-2-icosanamidooctadecyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: UGRZESKDAPEULH-ACEXITHZSA-N
SMILES: CCCCCCCCCCCCCCCCCCCC(N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(OCC[N+](C)(C)C)([O-])=O)=O
Biological Activity: C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0)) is a saturated form of Sphingomyelin (HY-113498). C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents[1][2][3].
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C20-Dihydrosphingomyelin | C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0)) is a saturated form of Sphingomyelin (HY-113498). C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents. | |||||||||||||||||||||
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References
- [1]. Madkour MI, et al. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis. Sci Rep. 2023 Oct 13;13(1):17322.
- [2]. Kasagi N, et al. Optimization of dihydrosphingomyelin/cholesterol mol ratio in topotecan-loaded liposomes to enhance drug retention and plasma half-life by understanding physicochemical and thermodynamic properties of the lipid membrane. Journal of Molecular Structure. 2023 Jul 5;1283:135333.
- [3]. Yano M, et al. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. J Lipid Res. 1998 Oct;39(10):2091-8. PMID: 9788256. [Content Brief]
