917613-59-3
Chemical Structure
MT-1207 free base
- CAS No.: 917613-59-3
- Formula:C21H24N6S
- Molecular Weight:392.52
InChIKey: GOALZWVIJQGFQJ-UHFFFAOYSA-N
SMILES: N1(CCCCN2CCN(CC2)C3=NSC4=C3C=CC=C4)N=NC5=C1C=CC=C5
Biological Activity: MT-1207 free base is an orally active, selective adrenergic α1 and 5-HT2A receptor antagonist. MT-1207 has IC50 values of <0.1 nM, 0.15 nM, 1.40 nM, and 0.27 nM for α1A, α1B, α1D, and 5-HT2A, respectively. MT-1207 free base induces vasodilation, improves baroreflex sensitivity, and reduces heart rate in isolated hearts. MT-1207 free base lowers blood pressure, protects the heart, brain, and kidneys, improves cognition, delays stroke, reduces mortality, and lowers uric acid without impairing renal function in SHR/2K1C/2K2C models. MT-1207 free base exhibits high plasma protein binding, resistance to plasma esterases, and NADPH-dependent hepatic metabolism. MT-1207 free base can be used for research related to hypertension[1][2][3].
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MT-1207 free base | MT-1207 free base is an orally active, selective adrenergic α1 and 5-HT2A receptor antagonist. MT-1207 has IC50 values of <0.1 nM, 0.15 nM, 1.40 nM, and 0.27 nM for α1A, α1B, α1D, and 5-HT2A, respectively. MT-1207 free base induces vasodilation, improves baroreflex sensitivity, and reduces heart rate in isolated hearts. MT-1207 free base lowers blood pressure, protects the heart, brain, and kidneys, improves cognition, delays stroke, reduces mortality, and lowers uric acid without impairing renal function in SHR/2K1C/2K2C models. MT-1207 free base exhibits high plasma protein binding, resistance to plasma esterases, and NADPH-dependent hepatic metabolism. MT-1207 free base can be used for research related to hypertension. | |||||||||||||||||||||
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References
- [1]. Tian JS, et al. Pharmacological effects of MT-1207 in bilateral renal artery stenosis hypertension and its hypotensive targets validation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Sep;178:117234. [Content Brief]
- [2]. Wang P, et al. Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension. Journal of medicinal chemistry. 2024 Sep 26;67(18):16128-16144. [Content Brief]
- [3]. Xu TY, et al. Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent. Acta pharmacologica Sinica. 2021 Jun;42(6):885-897.
