918523-75-8
918523-75-8
Chemical Structure
CDK8-IN-13
- CAS No.: 918523-75-8
- Formula:C14H11N3O
- Molecular Weight:237.26
IUPAC Name: 3-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
InChIKey: PQAJMNITAQGSCS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C2=CN=C3NC=CC3=C2)=C1)N
Biological Activity: CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC50 value of 51.9 nM. CDK8-IN-13 induces apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity[1].
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CDK8-IN-13 | 99.14% | CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC50 value of 51.9 nM. CDK8-IN-13 induces apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity. | ||||||||||||||||||||
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