925644-66-2
Chemical Structure
NFYi5
- CAS No.: 925644-66-2
- Formula:C19H22N6O
- Molecular Weight:350.42
InChIKey: YONNPZJSMHVSEF-UHFFFAOYSA-N
SMILES: CC1=C2C(C(C)=NC(NC3=NCN(CN3)CC4=CC=CO4)=N2)=CC(C)=C1
Biological Activity: NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis[1].
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NFYi5 | NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis. | |||||||||||||||||||||
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Keywords
