926922-16-9
926922-16-9
Chemical Structure
AP24163
- CAS No.: 926922-16-9
- Formula:C29H25F3N8O
- Molecular Weight:558.56
IUPAC Name: (E)-3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
InChIKey: XQBYDVRVYRYLCH-BQYQJAHWSA-N
SMILES: O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
Biological Activity: AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC50 values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML)[1].
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AP24163 | AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC50 values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML). | |||||||||||||||||||||
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