927822-45-5
927822-45-5
Chemical Structure
UC-1V150
- CAS No.: 927822-45-5
- Formula:C16H17N5O4
- Molecular Weight:343.34
IUPAC Name: 4-((6-amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzaldehyde
InChIKey: SHNIBVWXUOEWTA-UHFFFAOYSA-N
SMILES: O=CC1=CC=C(CN2C(NC3=C2N=C(OCCOC)N=C3N)=O)C=C1
Biological Activity: UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule[1][2].
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UC-1V150 | UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule. | |||||||||||||||||||||
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References
- [1]. Christina C N Wu, et al. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3990-5. [Content Brief]
- [2]. L N Dahal, et al. UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion. Scand J Immunol. 2018 Jun;87(6):e12666. [Content Brief]
Keywords
