942918-07-2
942918-07-2
Chemical Structure
GSK-1070916
Synonym(s): GSK-1070916A
- CAS No.: 942918-07-2
- Formula:C30H33N7O
- Molecular Weight:507.63
IUPAC Name: 3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea
InChIKey: QTBWCSQGBMPECM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C2=NN(C=C2C3=C4C(NC(C5=CC=CC(CN(C)C)=C5)=C4)=NC=C3)CC)C=C1)N(C)C
Biological Activity: GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK-1070916 | 99.54% | GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. | ||||||||||||||||||||
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GSK-1070916 (GMP) | GSK-1070916 (GMP) is GSK-1070916 (HY-70044) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.56
HY-184661MMV022224 -
Similarity Score 0.53
HY-126323BTCMDC-135051 hydrochloride -
Similarity Score 0.53
HY-126323TCMDC-135051 -
Similarity Score 0.51
HY-168990Ontunisertib -
Similarity Score 0.51
HY-176949STAT6-IN-10 -
Similarity Score 0.50
HY-18227B-Raf IN 1 -
Similarity Score 0.50
HY-169053SU1261 -
Similarity Score 0.50
HY-185073STAT6-IN-11 -
Similarity Score 0.50
HY-171290Casein kinase 1δ-IN-31 -
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