946080-23-5
946080-23-5
Chemical Structure
AZD1386
- CAS No.: 946080-23-5
- Formula:C19H13ClF3N3O3
- Molecular Weight:423.78
IUPAC Name: 5'-chloro-7'-methyl-1'-(3-(trifluoromethyl)benzyl)spiro[imidazolidine-4,3'-indoline]-2,2',5-trione
InChIKey: DXDVSYALLVVBOV-UHFFFAOYSA-N
SMILES: O=C1NC(=O)C2(N1)C(=O)N(C=3C(=CC(Cl)=CC32)C)CC4=CC=CC(=C4)C(F)(F)F
Biological Activity: AZD1386 is an orally active TRPV1 antagonist. AZD1386 blocks L-type calcium channels. AZD1386 can be used in pain research[1][2][3][4][5].
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AZD1386 | AZD1386 is an orally active TRPV1 antagonist. AZD1386 blocks L-type calcium channels. AZD1386 can be used in pain research. | |||||||||||||||||||||
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References
- [1]. Parkinson J, et al. Translational pharmacokinetic-pharmacodynamic modeling of QTc effects in dog and human. Journal of pharmacological and toxicological methods. 2013;68(3):357-66. [Content Brief]
- [2]. Trevisani M, et al. TRPV1 antagonists as analgesic agents. [Content Brief]
- [3]. Horoszok L, et al. Use of spiro[imidazolidine-4,3'-indole]-2,2',5'(1H)-triones for treatment of conditions associated with vanilloid receptor 1. WO 2007/091946 A1. 2007 Aug 16.
- [4]. Möller KÄ, et al. TRPV1 antagonist for OA pain: preclinical in vivo results predict clinical outcome. Osteoarthritis and Cartilage. 2016 Apr 1;24:S456.
- [5]. Möller KÄ, et al. Using gait analysis to assess weight bearing in rats with Freund׳ s complete adjuvant-induced monoarthritis to improve predictivity: interfering with the cyclooxygenase and nerve growth factor pathways. European journal of pharmacology. 2015 Jun 5;756:75-84. [Content Brief]
