949575-22-8
Chemical Structure
MIP-1095
Synonym(s): RPS-001
- CAS No.: 949575-22-8
- Formula:C19H25IN4O8
- Molecular Weight:564.33
IUPAC Name: (((S)-1-carboxy-5-(3-(4-iodophenyl)ureido)pentyl)carbamoyl)-L-glutamic acid
InChIKey: LFEGKCKGGNXWDV-KBPBESRZSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCNC(NC1=CC=C(I)C=C1)=O)=O
Biological Activity: MIP-1095 (RPS-001) is a PSMA inhibitor with a Ki value of 0.24 nM. MIP-1095 binds to PSMA with high affinity and can be internalized into PSMA-expressing cancer cells. When radiolabeled with 123I, 124I or 131I, MIP-1095 enables SPECT/CT imaging, PET/CT imaging or targeted radiation delivery, respectively. 131I-MIP-1095 can alter serum PSA levels and relieve bone pain. MIP-1095 can be used in research related to metastatic castration-resistant prostate cancer[1][2].
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MIP-1095 | MIP-1095 (RPS-001) is a PSMA inhibitor with a Ki value of 0.24 nM. MIP-1095 binds to PSMA with high affinity and can be internalized into PSMA-expressing cancer cells. When radiolabeled with 123I, 124I or 131I, MIP-1095 enables SPECT/CT imaging, PET/CT imaging or targeted radiation delivery, respectively. 131I-MIP-1095 can alter serum PSA levels and relieve bone pain. MIP-1095 can be used in research related to metastatic castration-resistant prostate cancer. | |||||||||||||||||||||
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References
- [1]. Hillier SM, et al. Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer. Cancer research. 2009 Sep 01;69(17):6932-40. [Content Brief]
- [2]. Zechmann CM, et al. Radiation dosimetry and first therapy results with a (124)I/ (131)I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy. European journal of nuclear medicine and molecular imaging. 2014 Jul;41(7):1280-92. [Content Brief]
