952295-80-6
Chemical Structure
PL-3994
- CAS. Nr.: 952295-80-6
- Formula:C82H127N27O20S2
- Molecular Weight:1875.18
InChIKey: HSHVZRILAMZYHY-MYZIVMFASA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CNC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CCCCCC)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)C)=O)=O)CCCNC(N)=N)=O)CCCC)=O)CC(O)=O)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CO)=O)=O)C(N5[C@H](C(N[C@H](C5)C(N)=O)=O)CCCNC(N)=N)=O
Biological Activity: PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC50 value of 42.7 nM[1].
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PL-3994 | PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC50 value of 42.7 nM. | |||||||||||||||||||||
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References
- [1]. Edelson JD, et al. In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 Apr;26(2):229-38. [Content Brief]
