955900-27-3
Chemical Structure
RK-9123016
- No. CAS: 955900-27-3
- Formula:C16H18N6O3S
- Molecular Weight:374.42
IUPAC Name: (E)-N-allyl-2-(4-methoxy-3-((4-nitro-1H-pyrazol-1-yl)methyl)benzylidene)hydrazine-1-carbothioamide
InChIKey: BSAOWQDRMYYMDT-QGMBQPNBSA-N
SMILES: O=[N+]([O-])C1=CN(N=C1)CC2=CC(/C=N/NC(NCC=C)=S)=CC=C2OC
Biological Activity: RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].
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RK-9123016 | 99.65% | RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression. | ||||||||||||||||||||
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