959860-49-2
959860-49-2
Chemical Structure
Guajadial
- CAS No.: 959860-49-2
- Formula:C30H34O5
- Molecular Weight:474.59
IUPAC Name: (2aS,4aS,10S,10aR,13aR)-7,9-dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobuta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
InChIKey: NSFVENNIBGTQJE-AHMOOTABSA-N
SMILES: OC(C(C=O)=C1O)=C(C(O2)=C1C=O)[C@H](C3=CC=CC=C3)[C@](CCC4=C)([H])[C@@]2(CC[C@@]5([H])[C@@]4([H])CC(C)5C)C
Biological Activity: Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].
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Guajadial | Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves. | |||||||||||||||||||||
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References
- [1]. Bazioli JM, et al. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.). Molecules. 2020 Mar 27;25(7):1525. [Content Brief]
- [2]. Li Y, et al. Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells. Chem Biol Interact. 2019 May 25;305:98-104. [Content Brief]
