960201-81-4
960201-81-4
Chemical Structure
SD-1008
- CAS No.: 960201-81-4
- Formula:C18H19NO5
- Molecular Weight:329.35
IUPAC Name: dimethyl (1R,5R,6R,7S)-8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylate
InChIKey: PYZQFEIRZQYUJQ-MIGQKNRLSA-N
SMILES: O=C([C@H]1[C@H](C2=O)N([C@H](C=C2)[C@H]1C(OC)=O)CC3=CC=CC=C3)OC
Biological Activity: SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SD-1008 | 99.10% | SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway. | ||||||||||||||||||||
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