97145-52-3
Chemical Structure
Arbortristoside A
- CAS No.: 97145-52-3
- Formula:C27H34O13
- Molecular Weight:566.55
IUPAC Name: methyl (1S,4aS,5S,6R,7R,7aR)-6-hydroxy-5-(((E)-3-(4-methoxyphenyl)acryloyl)oxy)-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
InChIKey: OQNPBHSDFWPQEK-HUCJFKJWSA-N
SMILES: COC(C=C1)=CC=C1/C=C/C(O[C@H]2[C@@]3([H])[C@]([C@H]([C@H]2O)C)([H])[C@@H](OC=C3C(OC)=O)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=O
Biological Activity: Arbortristoside A is an orally active inhibitor of prostaglandin (prostaglandin), histamine (histamine) and serotonin (serotonin). Arbortristoside A mediates anti-inflammatory, analgesic, anti-allergic, immunomodulatory, antiviral and anti-ulcerogenic effects, and also exhibits in vitro anticancer activity. Arbortristoside A can be used in research related to human hepatocellular carcinoma, breast cancer, fibrosarcoma, leishmaniasis, allergic diseases, viral infections and gastric ulcers[1][2][3][4].
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Arbortristoside A | Arbortristoside A is an orally active inhibitor of prostaglandin (prostaglandin), histamine (histamine) and serotonin (serotonin). Arbortristoside A mediates anti-inflammatory, analgesic, anti-allergic, immunomodulatory, antiviral and anti-ulcerogenic effects, and also exhibits in vitro anticancer activity. Arbortristoside A can be used in research related to human hepatocellular carcinoma, breast cancer, fibrosarcoma, leishmaniasis, allergic diseases, viral infections and gastric ulcers. | |||||||||||||||||||||
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References
- [1]. Das S, et al. Anti-inflammatory and antinociceptive activity of arbortristoside-A. Journal of ethnopharmacology. 2008 Feb 28;116(1):198-203. [Content Brief]
- [2]. Pandeti S, et al. Synthesis of novel anticancer iridoid derivatives and their cell cycle arrest and caspase dependent apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb 15;21(3):333-9.
- [3]. Agrawal J, et al. Nyctanthes arbor-tristis Linn--a critical ethnopharmacological review. Journal of ethnopharmacology. 2013 Apr 19;146(3):645-58.
- [4]. Mishra V, et al. Arbortristoside-A and 7-O-trans-cinnamoyl-6β-hydroxyloganin isolated from Nyctanthes arbortristis possess anti-ulcerogenic and ulcer-healing properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep 15;20(12):1055-63.
