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Cat. No.: HY-127080

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Arbortristoside A

Arbortristoside A is an orally active inhibitor of prostaglandin (prostaglandin), histamine (histamine) and serotonin (serotonin). Arbortristoside A mediates anti-inflammatory, analgesic, anti-allergic, immunomodulatory, antiviral and anti-ulcerogenic effects, and also exhibits in vitro anticancer activity. Arbortristoside A can be used in research related to human hepatocellular carcinoma, breast cancer, fibrosarcoma, leishmaniasis, allergic diseases, viral infections and gastric ulcers.

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CAS No.: 97145-52-3
Formule: C₂₇H₃₄O₁₃
Masse moléculaire:566.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Arbortristoside A Chemical Structure

CAS No.: 97145-52-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

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In Vitro

Parasitic InfectionViral InfectionOthers

Parasitic Infection

Arbortristoside A (compound AT) at concentrations of 30-100 μg/mL exhibits potent antileishmanial activity against Leishmania donovani amastigotes in vitro^[3].

Viral Infection

Arbortristoside A exhibits antiviral activity against encephalomyocarditis virus and Semliki Forest virus in vitro^[3].

Others

Arbortristoside A (0-125 μg/mL; 10 min pre-incubation, 20 min assay incubation) inhibits H⁺K⁺-ATPase activity in rat gastric microsomes, with an IC₅₀ of 103.86 μg/mL^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancerFungal InfectionOthers

Anti-cancer

Arbortristoside A (compound AT) (2.5 mg/kg) exhibits anticancer activity in methylcholanthrene-induced fibrosarcoma mice^[3].

Fungal Infection

Arbortristoside A (5 mg/kg; i.g.; single dose) exhibits immunomodulatory activity in mice, protects against systemic Candida albicans infection and enhances immune responses^[3].

Others

Arbortristoside-A (50-75 mg/kg; i.p.; single administration) dose-dependently inhibits paw edema in Wistar albino rats induced by Carrageenan (HY-125474), Arachidonic acid (HY-109590), Histamine (HY-B1204) and Serotonin (HY-B1473A)^[1].
Arbortristoside-A (50-75 mg/kg; i.p.; single administration) dose-dependently inhibits acetic acid (HY-Y0319)-induced writhing response in Swiss albino mice^[1].
Arbortristoside-A (50-75 mg/kg; i.p.; single administration) dose-dependently prolongs the pain response time of Swiss albino mice tested by the Eddy hot-plate method^[1].
Arbortristoside A (10-40 mg/kg; p.o.; single administration) dose-dependently protects rats against cold restraint stress-induced gastric ulcers^[4].
Arbortristoside A (20 mg/kg; p.o.; single dose) exerts a significant protective effect against ethanol-induced gastric ulcers in rats^[4].
Arbortristoside A (20 mg/kg; p.o.; single administration) exerts a 48.45% protective effect against Aspirin (HY-14654)-induced gastric ulcers in rats^[4].
Arbortristoside A (20 mg/kg; p.o.; single administration) exerts a 50.0% protective effect against pylorus ligation-induced gastric ulcers in rats, while reducing gastric acid secretion and increasing mucin production^[4].
Arbortristoside A (20 mg/kg; p.o.; once daily; for 10 consecutive days) increases the healing rate of acetic acid-induced chronic gastric ulcers in rats to 55.94%^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar albino (weighing 150-180 g)^[1]
Dosage:

50, 75 mg/kg
Administration:

i.p.; single dose
Result:

Reduced paw edema.

Animal Model:

Swiss albino (weighing 18-22 g)^[1]
Dosage:

50, 75 mg/kg
Administration:

i.p.; single dose
Result:

Reduced Acetic acid-induced writhing counts.

Animal Model:

Swiss albino (weighing 18-22 g; fasted for 12 hours with access to water)^[1]
Dosage:

50, 75 mg/kg
Administration:

i.p.; single dose
Result:

Increased pain reaction time.

Animal Model:

Sprague-Dawley (adult female, 180-220 g, chronic acetic acid-induced)^[4]
Dosage:

20 mg/kg
Administration:

p.o.; daily; 10 days
Result:

Provided 55.94% ulcer healing compared to controls.
Increased gastric mucosal PGE₂ levels to 3857 pg/mg protein from control level of 2551 pg/mg protein.
Restored mucosal epithelium, reduced inflammatory exudates, and improved glandular organization based on histopathology.
Suppressed ulcer-induced increase in TNF-α and IL-1β mRNA expression.
Left COX-1 expression unchanged relative to sham and control groups.

Related Protocols :

Chemical Information

CAS No. 97145-52-3
Masse moléculaire 566.55
Formule C₂₇H₃₄O₁₃
SMILES

COC(C=C1)=CC=C1/C=C/C(O[C@H]2[C@@]3([H])[C@]([C@H]([C@H]2O)C)([H])[C@@H](OC=C3C(OC)=O)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Das S, et al. Anti-inflammatory and antinociceptive activity of arbortristoside-A. Journal of ethnopharmacology. 2008 Feb 28;116(1):198-203. [Content Brief]

[2]. Pandeti S, et al. Synthesis of novel anticancer iridoid derivatives and their cell cycle arrest and caspase dependent apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb 15;21(3):333-9.

[3]. Agrawal J, et al. Nyctanthes arbor-tristis Linn--a critical ethnopharmacological review. Journal of ethnopharmacology. 2013 Apr 19;146(3):645-58.

[4]. Mishra V, et al. Arbortristoside-A and 7-O-trans-cinnamoyl-6β-hydroxyloganin isolated from Nyctanthes arbortristis possess anti-ulcerogenic and ulcer-healing properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep 15;20(12):1055-63.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Arbortristoside A

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