973-67-1
973-67-1
Chemical Structure
5,6,7-Trimethoxyflavone
Synonym(s): Baicalein trimethyl ether
- CAS No.: 973-67-1
- Formula:C18H16O5
- Molecular Weight:312.32
IUPAC Name: 5,6,7-trimethoxy-2-phenyl-4H-chromen-4-one
InChIKey: HJNJAUYFFFOFBW-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(OC)C(OC)=C13
Biological Activity: 5,6,7-Trimethoxyflavone is a flavonoid compound that can be isolated from plants Callicarpa japonica. 5,6,7-Trimethoxyflavone exhibits antiviral and anti-inflammatory activities through inhibition of NF-κB/AP-1/STAT signaling pathway[1][2].
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5,6,7-Trimethoxyflavone | 98.02% | 5,6,7-Trimethoxyflavone is a flavonoid compound that can be isolated from plants Callicarpa japonica. 5,6,7-Trimethoxyflavone exhibits antiviral and anti-inflammatory activities through inhibition of NF-κB/AP-1/STAT signaling pathway. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-N178505-Hydroxy-6,7-dimethoxyflavone -
Similarity Score 0.89
HY-N2036Mosloflavone -
Similarity Score 0.85
HY-N76565,7,8-Trimethoxyflavone -
Similarity Score 0.82
HY-N4285Negletein -
Similarity Score 0.82
HY-N50115,7-Dimethoxyflavone -
Similarity Score 0.82
HY-N4314Scutellarein tetramethyl ether -
Similarity Score 0.82
HY-N1318RSalvigenin (Standard) -
Similarity Score 0.81
HY-N0560ROroxylin A (Standard) -
Similarity Score 0.81
HY-N2035Moslosooflavone -
Explore the MedChemAI to find more analogs
References
- [1]. Hayashi K, et al., Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir. J Antimicrob Chemother. 1997 Jun;39(6):821-4. [Content Brief]
- [2]. Rim HK, et al., 5,6,7-trimethoxyflavone suppresses pro-inflammatory mediators in lipopolysaccharide-induced RAW 264.7 macrophages and protects mice from lethal endotoxin shock. Food Chem Toxicol. 2013 Dec;62:847-55. [Content Brief]
