98819-76-2
Chemical Structure
Esreboxetine
Synonym(s): (S,S)-(+)-Reboxetine
- CAS No.: 98819-76-2
- Formula:C19H23NO3
- Molecular Weight:313.39
IUPAC Name: (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine
InChIKey: CBQGYUDMJHNJBX-OALUTQOASA-N
SMILES: CCOC(C=CC=C1)=C1O[C@H]([C@]2([H])CNCCO2)C3=CC=CC=C3
Biological Activity: Esreboxetine ((S,S)-Reboxetine) is a selective norepinephrine transporter (NET) inhibitor, with a pIC50 of 9.6 and a pKi of 9.2 in rats, and it can cross the blood-brain barrier. Esreboxetine increases urethral closure pressure and urethral resistance in rats. Esreboxetine is applicable to research related to inflammatory pain and stress urinary incontinence[1][2].
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Esreboxetine | Esreboxetine ((S,S)-Reboxetine) is a selective norepinephrine transporter (NET) inhibitor, with a pIC50 of 9.6 and a pKi of 9.2 in rats, and it can cross the blood-brain barrier. Esreboxetine increases urethral closure pressure and urethral resistance in rats. Esreboxetine is applicable to research related to inflammatory pain and stress urinary incontinence. | |||||||||||||||||||||
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References
- [1]. Shen F, et al. Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. PloS one. 2013;8(9):e74891.
- [2]. Fujimori I, et al. Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor. Bioorg Med Chem. 2015 Aug 1;23(15):5000-5014. [Content Brief]
