99624-27-8
99624-27-8
Chemical Structure
Kazinol B
- CAS No.: 99624-27-8
- Formula:C25H28O4
- Molecular Weight:392.49
IUPAC Name: (S)-6-(7-hydroxychroman-2-yl)-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H-chromen-8-ol
InChIKey: QSCBHDIGHKHWKC-NRFANRHFSA-N
SMILES: C/C(C)=C/CC1=C([C@H]2OC3=CC(O)=CC=C3CC2)C=C4C(OC(C)(C)C=C4)=C1O
Biological Activity: Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2].
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Kazinol B | Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research. | |||||||||||||||||||||
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References
- [1]. Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. [Content Brief]
- [2]. Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74(4):350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. [Content Brief]
