Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki

  • Fitoterapia. 2003 Jun;74(4):350-4. doi: 10.1016/s0367-326x(03)00062-5.
Jae-Ha Ryu  1 ,  Hanna Ahn ,  Hwa Jin Lee
Affiliations
  • 1. College of Pharmacy, Sookmyung Women's University, Seoul 140-742, South Korea. [email protected]
PMID: 12781805 DOI: 10.1016/s0367-326x(03)00062-5
Abstract

The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 microg/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC(50) of 21.6 microM.

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