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Cat. No.: HY-135225

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CH 402

CH 402 is an antioxidant and radioprotective agent. CH 402 reduces the level of ⁶⁰Co-γ ray-induced lipid peroxidation in in vitro liver microsomal preparations. CH 402 inhibits ascorbate-induced non-enzymatic lipid peroxidation in brain homogenates and microsomal fractions of rodents.

For research use only. We do not sell to patients.

CAS No.: 75903-70-7
Formula: C₁₂H₁₄NNaO₃S
Molecular Weight:275.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

CH 402 Chemical Structure

CAS No.: 75903-70-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
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Chemical Information
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Biological Activity

Description

In Vitro

CH 402 acts as a radioprotective agent by reducing lipid peroxidation induced by ⁶⁰Co-γ ray irradiation in liver microsomes of both amiodarone-treated and control rats^[1].
CH 402 (0-20 min) inhibits ascorbate-induced lipid peroxidation in brain homogenates and brain microsomal fractions of Wistar rats, as well as in brain homogenates and brain microsomal fractions of CBA/Ca mice, with an IC₅₀ of 0.5 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 75903-70-7
Molecular Weight 275.30
Formula C₁₂H₁₄NNaO₃S
SMILES

O=S(CC1=CC(C)(C)NC2=C1C=CC=C2)(O[Na])=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vereckei A, et al. The role of free radicals in the pathogenesis of amiodarone toxicity. Journal of cardiovascular electrophysiology. 1993 Apr;4(2):161-77.

[2]. Blázovics A, et al. Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402). Free radical research communications. 1988;4(6):409-13.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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