2'-Deoxy-PTX
2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and microtubule assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Kaapp of 0.50 × 106 M-1. 2′-Deoxy-PTX induces Tubulin to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 156413-68-2
- Formel: C47H51NO13
- Molecular Weight:837.91
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
In Vitro
2'-Deoxy-PTX (15 μM; up to 25 min) induces the assembly of purified tubulin into normal microtubules at 37 °C[1].
2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules at 37 °C, with an apparent binding constant of 0.50 × 106 M-1[1].
2'-Deoxy-PTX exhibits an IC50 of 526 nM against PC3 cells, with significantly reduced cytotoxicity compared with PTX[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 156413-68-2
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Molecular Weight 837.91
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Formel C47H51NO13
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SMILES
CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC(C[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C)C)O)OC(C7=CC=CC=C7)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
2'-Deoxy-PTX Related Classifications
HY-185269 Related Classifications
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