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Carfilzomib

(Synonyms: PR-171)
74 Cited Publications
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Based on 74 publication(s) in Google Scholar

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

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  • Reinheit: 99.95%
  • CAS. Nr.: 868540-17-4
  • Formel: C40H57N5O7
  • Molecular Weight:719.91
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • Carfilzomib Chemical Structure
    Carfilzomib Chemical Structure
  • Experimental Validation Results for Carfilzomib
  • Experimental Validation Results for Carfilzomib
  • Experimental Validation Results for Carfilzomib
  • Experimental Validation Results for Carfilzomib
  • Experimental Validation Results for Carfilzomib
CAS. Nr.: 868540-17-4
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  • Carfilzomib Chemical Structure
    Carfilzomib Chemical Structure
    1/16
  • 1/16

    Carfilzomib purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118368. [Abstract]

    Customer Validation
     Carfilzomib (0.1-1000 μM; 24 h). Cell viability of RPMI 8226 cells after treatment with raw CFZ (Carfilzomib) for 24 h.

  • 1/16

    Carfilzomib purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Jul 8;42(7):1286-1300.e8. [Abstract]

    Customer Validation
     KP-1 cells were treated with vehicle, Carfilzomib (200 nM; 48 h) for 48 h. Ifi30, Irf7, Ddx60 expression levels are assessed using RT-PCR.

  • 1/16

    Carfilzomib purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 30;13(6):671. [Abstract]

    Customer Validation
     Carfilzomib (8 mg/kg; i.p.; 2 consecutive days). Photomicrographs presents histopathological alterations along the heart tissue sections among the studied groups (hematoxylin and eosin stain, magnification power = 400×, and scale bar = 50 µm). Sections from control mice and EMPA-alone-treated mice demonstrates standard myocardial fibers with intact myocytes (arrows). CFZ (Carfilzomib)-treated mice highlights degenerated and necrotic cardiomyocytes (circle), nuclear pyknosis (arrow), increase in intermuscular spaces (arrow with tail), hemorrhagic spots (star), infiltration of inflammatory cells (wave arrow), fat cells (arrowhead), and congested vasculatures (rectangle). EMPA + CFZ-treated mice discloses many apparent intact cardiomyocytes (arrow), scarce apoptotic cardiomyocytes (curvy arrow), and congested vasculatures (rectangle).

  • 1/16

    Carfilzomib purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Oct:156:511-523. [Abstract]

    Customer Validation
     J-Lat 10.6 cells are treated with DMSO, PR-957 (150 nM) or Carfilzomib (40 nM) alone with or without the HSF1 inhibitor KRIBB11 (1.25 µM) for 48 h. Then the cells are lysed, and Ser320 phosphorylated HSF1, total HSF1 and p24 are detected by Western blot with the corresponding antibodies.

  • 1/16

    Carfilzomib purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2017 Jun 7;65(22):4384-4394. [Abstract]

    Customer Validation
     Resveratrol activates the HSF1 signaling pathway. J-Lat A2 cells are treated with various concentrations of Resveratrol or Carfilzomib (50 nM) for 48 h. Then the cells are lysed and Ser320 phosphorylated HSF1 and total HSF1 are detected by Western blot with corresponding antibodies.

  • Carfilzomib