Ferrochelatase
Ferrochelatase
Ferrochelatase is a key enzyme involved in heme biosynthesis. Ferrochelatase can catalyze the binding of ferrous ions to protoporphyrin IX to form heme. In the heme synthesis pathway, Ferrochelatase is involved in the last crucial reaction, ensuring the normal synthesis of heme in organisms. This provides a material basis for the functions of heme-containing proteins such as hemoglobin and myoglobin, thus guaranteeing the smooth progress of important physiological processes such as oxygen transport and cellular respiration. Abnormalities in Ferrochelatase activity are closely related to diseases such as hereditary erythropoietic protoporphyria[1].
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Ferrochelatase Verwandte Produkte (5)
Verwandte Produkte (5)
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Pyridoxal isonicotinoyl hydrazone
0 ImagesPyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia).
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Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
0 ImagesDiethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC).
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N-Methylprotoporphyrin IX
0 ImagesN-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Kiapp value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders.
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Ni(II) protoporphyrin IX
0 ImagesArt. -Nr.: HY-136476CCAS. Nr.: 15415-30-2Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase.
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Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard)
0 ImagesArt. -Nr.: HY-118594RCAS. Nr.: 632-93-9Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard) is the analytical standard of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HY-118594). This product is intended for research and analytical applications. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC).
