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Art. -Nr.: HY-178276

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α-Synuclein-IN-18

α-Synuclein-IN-18 (Compound Mol D) is an inhibitor of the autocatalytic proliferation of α-Synuclein aggregate. α-Synuclein-IN-18 can specifically bind to the conserved binding pocket on the surface of α-synuclein fibrils. α-Synuclein-IN-18 can delay the aggregation process of α-synuclein, extend the aggregation T_1/2 by three times. α-Synuclein-IN-18 can reduce the generation flux of α-synuclein toxic oligomers, thereby alleviating the neurotoxicity. α-Synuclein-IN-18 can be used for research of Parkinson’sdisease.

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CAS. Nr.: 1394328-54-1
Formel: C₁₆H₁₆N₄O₂
Molecular Weight:296.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

α-Synuclein-IN-18 Chemical Structure

CAS. Nr.: 1394328-54-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Alle α-synuclein Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 1394328-54-1
Molecular Weight 296.32
Formel C₁₆H₁₆N₄O₂
SMILES

O=C(C1NCCC2=C1N=C(C3=CNC4=C3C=CC=C4C)N2)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chia S, et al. Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates. Mol Pharm. 2023 Jan 2;20(1):183-193. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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α-Synuclein-IN-18

Alle α-synuclein Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

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Calculators

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α-Synuclein-IN-18 Related Classifications

HY-178276 Related Classifications

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