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Art. -Nr.: HY-189345

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Antileishmanial agent-45

Antileishmanial agent-45 is a C6-substituted eugenol derivative bearing a 1,2,3-triazole linker directly attached to the aromatic ring, a free phenolic hydroxyl group, and a benzyloxy substituent. Antileishmanial agent-45 retains and enhances the antileishmanial activity of its natural-product precursor eugenol. Antileishmanial agent-45 can be used for the research of leishmaniasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₁H₂₃N₃O₄
Molecular Weight:381.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antileishmanial agent-45 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Peritoneal macrophage	CC₅₀	200 μM	Cytotoxicity against uninfected murine intraperitoneal macrophages assessed as 50% cytotoxic concentration incubated for 72 hrs. Cytotoxicity against uninfected murine intraperitoneal macrophages assessed as 50% cytotoxic concentration incubated for 72 hrs.	42662206

In Vitro

Antileishmanial agent-45 (compound 4D) (72 h) exhibits potent in vitro activity against L. amazonensis promastigotes with an IC₅₀ of 11.60 μM^[1].
Antileishmanial agent-45 (72 h) is the most active compound against L. amazonensis amastigotes, with an IC₅₀ of 3.98 μM^[1].
Antileishmanial agent-45 (72 h) exhibits low cytotoxicity against mouse macrophages (CC₅₀ > 200 μM) and a high selectivity index (> 50.25)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 381.43
Formel C₂₁H₂₃N₃O₄
SMILES

C=CCC1=CC(OC)=C(O)C(N2N=NC(COCC3=CC=C(OC)C=C3)=C2)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Orenha HP, et al. Design, Synthesis, and Antileishmanial Activity of Novel C6-Substituted Eugenol Derivatives with a Triazole Linker. ACS omega. 2026 Aug 25;11(33):49026-49032.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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