58546-00-2
58546-00-2
Chemical Structure
N-Nornuciferine hydrochloride
- CAS. Nr.: 58546-00-2
- Formula:C18H20ClNO2
- Molecular Weight:317.81
InChIKey: RBJGEWHGFMPNFU-PFEQFJNWSA-N
SMILES: COC1=C2C3=C(C=C1OC)CCN[C@]3([H])CC4=CC=CC=C42.Cl
Biological Activity: N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases[1][2][3].
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N-Nornuciferine hydrochloride | N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases. | |||||||||||||||||||||
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References
- [1]. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014;153(1):190-196. [Content Brief]
- [2]. Ye LH, et al. Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain. Front Pharmacol. 2018 Aug 29;9:902. [Content Brief]
- [3]. Cometa MF, et al. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr;83(3):476-80. [Content Brief]
